The screw–helical voltage gating of ion channels
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چکیده
منابع مشابه
Voltage- and cold-dependent gating of single TRPM8 ion channels
Transient receptor potential (TRP) channels play critical roles in cell signaling by coupling various environmental factors to changes in membrane potential that modulate calcium influx. TRP channels are typically activated in a polymodal manner, thus integrating multiple stimuli. Although much progress has been made, the underlying mechanisms of TRP channel activation are largely unknown. The ...
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Voltage-gated sodium channels activate in response to depolarization, but it is unknown whether the voltage-sensing arginines in their S4 segments pivot across the lipid bilayer as voltage sensor paddles or move through the protein in a gating pore. Here we report that mutation of pairs of arginine gating charges to glutamine induces cation permeation through a gating pore in domain II of the N...
متن کاملAllosteric Voltage Gating of Potassium Channels II
Large-conductance Ca(2+)-activated K(+) channels can be activated by membrane voltage in the absence of Ca(2+) binding, indicating that these channels contain an intrinsic voltage sensor. The properties of this voltage sensor and its relationship to channel activation were examined by studying gating charge movement from mSlo Ca(2+)-activated K(+) channels in the virtual absence of Ca(2+) (<1 n...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of London. Series B: Biological Sciences
سال: 1999
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.1999.0714